Cd10

Acronym for Cluster of differentiation(CD). CD10 also called "Common acute leukemia antigen, CALLA, is a zinc(II)-dependent membrane-bound, 100-kDa endopeptidase involved in the processing of signal peptides. These include the natriuretic peptides ANP, BNP and bradykinin and the neurotoxic CNS peptide beta-amyloid.

These processes play a role in various diseases, such as Alzheimer's disease, as well as in different tumour entities, such as malignant melanoma.

The CD10 antibody serves as a marker for: B and T progenitor cells, granulocytes, various cells of epithelial origin and fibroblasts. CD10 is useful in the diagnosis of lymphoblastic BCL and CML ( Application: FACS, IHC (P) (G), IF).

CD10 is a membrane associated neutral endopeptidase. CD10 is helpful in the diagnosis of lymphoblastic leukemia, follicular lymphoma and Burkitt's lymphoma. CD10 is positive in atypical fibroxanthomas and histiocytomas and is similar to the BCL6 protein.

In metastatic malignant melanoma CD10 is expressed in a stronger way than in primary tumors. Apparently, tumor progression and a worse prognosis in malignant melanomas is associated with a stronger expression of CD10. Furthermore, the expression of CD10 by connective tissue cells is considered to be an important factor in the tumor invasiveness of colorectal, gastric, breast and skin cancers[carcinoma, cutaneous].

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.