DefinitionThis section has been translated automatically.
CCR4 (C-C Motif Chemokine Receptor 4) is a protein-coding gene located on chromosome 3p22.3 that encodes the eponymous, CCR4 receptor. The CCR4 receptor protein belongs to the G protein-coupled transmembrane chemokine receptor family.
DefinitionThis section has been translated automatically.
CCR4 (CCR4 stands for C-C Motif Chemokine Receptor 4) receptor protein encoded by the gene of the same name(CCR4 gene). The CCR4 receptor protein belongs to the family of G-protein-coupled transmembrane chemokine receptors. CCR4 is a high-affinity receptor for the C-C chemokines CCL3 (MIP-1), CCL4 (RANTES), CCL17 (TARC) and MCP-1. The activity of the CCR4 protein is mediated by G(i) proteins that activate a phosphatidylinositol calcium second messenger system. The receptor may function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, it appears to be important for the survival of hippocampal neurons.
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General informationThis section has been translated automatically.
Chemokine CC receptors (CCRs) predominantly recognize CC chemokines (Yoshie O et al. 2015). Chemokines are a group of small, structurally related polypeptide molecules that regulate cell traffic of various leukocyte types. Chemokines also play a fundamental role in the development, homeostasis and function of the immune system and have effects on cells of the central nervous system as well as endothelial cells involved in angiogenesis. CC chemokines are characterized by the fact that they have four conserved cysteines. In the CC chemokines, the cysteines follow each other directly, in the CXC chemokines they are separated by 1 amino acid (CC = acronym for cysteine-cysteine), in the CXXXC chemokines by 3 other amino acids.
LiteratureThis section has been translated automatically.
- Ferenczi K et al. (2002) Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol 119:1405-1410.
- Ishida Tet al. (2006) CCR4 as a novel molecular target for immunotherapy of cancer. Cancer Sci 97:1139-1146.
- Shimauchi T et al. (2005) Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells. Clin Cancer Res 11:2427-2435.
- Yoshie O et al. (2015) CCR4 and its ligands: from bench to bedside. Int Immunol 27:11-20.
