Cathepsin b

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Cathepsin B

Definition
This section has been translated automatically.

Cathepsin B (cathepsin from Greek καθεψειν = digest) is an endoprotease which is found in lysosomes of eosinophilic granulocytes and osteoclasts, among others. Cathepsin B is encoded by the CBS gene.

Cathepsin B is upregulated in premalignant lesions, but also in the lesional areas of cornification disorders such as keratolytic winter erythema. Mutations in the CTSB gene are associated with a form of chronic pancreatitis.

General information
This section has been translated automatically.

Cathepseins generally cause a hydrolytic degradation of the extracellular matrix and the basement membrane when released. Known are > 10 cathepsins such as Cathepsin B, Cathepsin H, Cathepsin K, Cathepsin L; Cathepsin S.

In suspended meat, released enzymes, e.g. cathepsins and calpains, cause the meat to become increasingly tender (meat maturation) due to their incipient, continuous enzymatic activity.

Incoming links (1)

Keratolytic winter erythema;

Outgoing links (1)

Keratolytic winter erythema;

Authors

Last updated on: 29.10.2020