Calcipotriol

Author: Prof. Dr. med. Peter Altmeyer

Co-Autor: Dr. med. Florian Weid

All authors of this article

Last updated on: 18.12.2020

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Definition
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Vitamin D3 analogue.

Indication
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Mild to moderate psoriasis vulgaris of the plaque type with an extension of < 30% of the body surface.

Dosage and method of use
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Ointment/cream/compound: Apply 2 times/day to the affected areas of skin (max. 30% of the body surface, max. 15 g ointment/cream/day, max. for 6 weeks) The cream base or a solution can also be used in the area of the capillitium, as it can be washed out easily!

Standard concentration
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0.005% in lotions, ointments, creams.

Undesirable effects
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  • Cream/Ointment: Occasional temporary itching, burning and erythema, especially in intertriginous areas. Occurrence of facial and perioral dermatitis (see also eczema, contact eczema, allergic), which disappears after the end of treatment. Continuous use of high doses may result in hypercalcemia and/or increased urinary calcium excretion.
  • Solution: See above, in addition possibly worsening of psoriasis, sensitivity to light, rarely hypercalcemia, hypercalzuria.

Interactions
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Calcium preparations, salicylic acid, cream bases without active ingredients.

Contraindication
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Pregnancy, lactation, children and adolescents < 18 years, large-area application (> 30% KO), psoriasis punctata, pustular psoriasis, diseases of the calcium metabolism, severe liver and kidney diseases.

Incompatibility
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Exteriors containing salicylic acid inactivate calcipotriol when used simultaneously and even after hours of use.

Preparations
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Daivonex® - cream, ointment, solution

Daivobet® - gel, ointment (combination with betamethasone dipropionate)

Xamiol® - gel (combination with betamethasone dipropionate)

Enstilar® - foam (spray foam galenic, also combination with betamethasone diproprionate)

Dovobet® - gel (combination with betamethasone diproprionate)

Calcipotriol - Solution

Calcipotriol Comp - Ointment

Patientinformation
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Wash your hands after use to avoid transfer to the facial skin and other non-diseased skin areas!

Authors

Last updated on: 18.12.2020