Synonym(s)
calcinosis interstitialis; Calcinosis lipogranulomatosa progressive; calcinosis metabolica unversalis; disseminated dystrophic calcinosis; German Nationality Syndrome; Lipocalcinogranulomatosis; Lipoid lime gout; Progressive lipocalcinosis
HistoryThis section has been translated automatically.
Germany, 1935; Inclan et al., 1943
DefinitionThis section has been translated automatically.
Rare disease with deposition of calcium salts in the cutaneous and subcutaneous tissue as well as the musculature without tangible calcium or phosphate metabolic disorder.
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EtiopathogenesisThis section has been translated automatically.
Occurs mainly in systemic diseases such as systemic scleroderma, Ehlers-Danlos syndrome, Pseudoxanthoma elasticum, Progeria adultorum. S.a.u. Myositis ossificans.
LocalizationThis section has been translated automatically.
Extremities here around the large joints, also on the trunk.
Clinical featuresThis section has been translated automatically.
Mostly symmetrical, multiple calcifications in the skin. Inflammatory redness, perforation, discharge of a calcareous, creamy or purulent appearing material. Poorly healing ulcerations, formation of retracted scars. Possibly painful restriction of movement in the case of calcified deposits near joints.
HistologyThis section has been translated automatically.
Calcareous salt deposits in the subcutaneous and cutaneous tissue.
Differential diagnosisThis section has been translated automatically.
Myositis ossificans; gout; other forms of calcinosis cutis.
TherapyThis section has been translated automatically.
Treatment of the underlying disease. As far as possible surgical removal of circumscribed or painful calcific knots. In case of ulceration, wound cleansing and granulation promoting measures, see wound treatment below. In case of severe inflammatory changes glucocorticoids can be applied externally such as 0.25% prednicarbate (e.g. Dermatop cream).
Progression/forecastThis section has been translated automatically.
Chronic progressive course with remissions.
LiteratureThis section has been translated automatically.
- Inclan A, Leon P, Gomez CM (1943) Tumoral calcinosis. JAMA 121: 490-495
- German O (1935) About progressive lipogranulomatosis of the musculature. At the same time a contribution to the pathogenesis of osteopathia osteoplastica progressiva. Clin weekday 14: 451
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Incoming links (8)
Calcinosis dystrophica; Calcinosis interstitialis; Calcinosis lipogranulomatosa progressive; Calcinosis metabolica; German nationality syndrome; Lipocalcinogranulomatosis; Lipoid lime gout; Progressive lipocalcinosis;Outgoing links (8)
Calcinosis cutis (overview); Ehlers-danlos syndrome; Glucorticosteroids topical; Gout; Progeria adultorum; Pseudoxanthoma elasticum; Scleroderma systemic; Wound treatment;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer