Synonym(s)
HER-2/new
DefinitionThis section has been translated automatically.
The c-erb-2 oncoprotein is a cytoplasmic epitope that is mainly expressed in breast carcinomas and their metastases. A c-erB-2 overexpression is associated with a poor prognosis. Overexpression of the c-erB-2 oncoprotein is therapeutically relevant in breast cancer. C-erB-2 is an important marker of intaepidermal mammary Paget cells.
Prof. Dr. med. Peter Altmeyer