Bimatoprost

Bimatoprost is an active substance from the group of prostaglandin analogues. Eye drops containing bimatoprost are used to reduce increased intraocular pressure in chronic open-angle glaucoma and ocular hypertension. The preparation is instilled into the affected eyes once a day in the evening.

The effect is based on an increase in the outflow of aqueous humor via the trabecular meshwork and an increase in uveoscleral outflow.

Hypersensitivity reactions including signs and symptoms of allergic dermatitis, asthma, asthma exacerbation, COPD exacerbation, and dyspnea of unknown frequency. Dry eye is also reported. Occasionally (≥1/1,000 to <1/100) cystoid macular edema has been reported.

Hyperpigmentation of the iris is rarer. These are probably permanent. The altered pigmentation is caused by an increased melanin content of the melanocytes. After 12 months the frequency was 1.5% with bimatoprost 0.3 mg/ml eye drops. Periorbital tissue pigmentation was reported to be reversible in some patients.

In the USA, Bimatoprost is additionally approved for the promotion of eyelash growth. It increases the number of eyelashes, lengthens them and strengthens their pigmentation.