B-cell regulatory

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Breg; regulatory B cell

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DefinitionThis section has been translated automatically.

Regulatory cells are essential for immunological homeostasis and immunotolerance, with the regulatory T cell (Treg) playing a central role. It has been shown that B cells (CD19, CD24, CD38) can also perform regulatory functions. For example, B cells inhibit the differentiation of T-helper 1 cells (Th1). This is achieved by the expression of IL-10 and the involvement of CD80 and CD86. There is evidence that B cells from patients with systemic lupus erythematosus have a reduced regulatory capacity compared to CD4+T cells, regardless of their origin. S.a.u. regulatory T cell (Treg).

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer