Anti-p105 pemphigoid L12.0

Rare acute, non-scarring, blistering autoimmune disease from the group of pemphigoids.

Clinically, this non-scarring dermatosis is characterized by the sudden appearance of extensive blisters and erosions in the skin and mucous membrane, similar to toxic epidermal necrolysis or pemphigus vulgaris.

Histologically a subepithelial blistering with a papillary neutrophil infiltration (see also dermatitis herpetiformis)is found in lesional skin.

Linear IgG and C3 deposition at the dermo-epidermal junction. Detectable antigen is a 105 kDa protein located in the lower parts of the lamina lucida.

Azathioprine and prednisolone led to permanent remission.

1. Chan LS (1997) Human skin basement membrane in health and in autoimmune diseases. Front Biosci 2:d343-52.
2. Georgi M et al (2001) Autoantigens of subepidermal bullous autoimmune dermatoses. Dermatologist 52:1079-1089.