Synonym(s)
anti-p-105 pemphigoid
DefinitionThis section has been translated automatically.
Rare acute, non-scarring, blistering autoimmune disease from the group of pemphigoids.
Clinical featuresThis section has been translated automatically.
Clinically, this non-scarring dermatosis is characterized by the sudden appearance of extensive blisters and erosions in the skin and mucous membrane, similar to toxic epidermal necrolysis or pemphigus vulgaris.
You might also be interested in
HistologyThis section has been translated automatically.
Histologically a subepithelial blistering with a papillary neutrophil infiltration (see also dermatitis herpetiformis)is found in lesional skin.
Direct ImmunofluorescenceThis section has been translated automatically.
Linear IgG and C3 deposition at the dermo-epidermal junction. Detectable antigen is a 105 kDa protein located in the lower parts of the lamina lucida.
TherapyThis section has been translated automatically.
Azathioprine and prednisolone led to permanent remission.
LiteratureThis section has been translated automatically.
- Chan LS (1997) Human skin basement membrane in health and in autoimmune diseases. Front Biosci 2:d343-52.
- Georgi M et al (2001) Autoantigens of subepidermal bullous autoimmune dermatoses. Dermatologist 52:1079-1089.
Recommended articles
Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer