Angiolipoma D17.9

Howard and Helwig 1960

Benign, solitary or multiple, slow-growing, often painful, vascular, ubiquitous nodules, which may be soft or firm.

Extremities, trunk, even on the face.

Sharply defined, shifting, relatively coarse, subcutaneous node. Frequently pressure-treated. Angiolipomas occur in > 50% of patients in the majority.

Circumscribed lobular tumor node made of mature adipocytes and provided with a delicate connective tissue capsule. A second tissue component is abundantly formed, often thrombosed vessels. A protruding or dominant vascular component is called a cell-rich angiolipoma (cellular angiolipoma). The cell-rich angiolipoma can occur together with the conventional lipoma. It shows reactivity for CD31 and CD34.

Histological:

• Kaposi's Sarcoma
• Kaposi's angioendothelioma
• Angiosarcoma

Excision, in case of multiple occurrence, if necessary, drug therapy for pain.

1. Alonso S et al (2003) Metastasis of cutaneous malignant melanoma to angiolipoma: the tumor-to-tumor metastasis phenomenon. J Cutan catheter 30: 323-325
2. Behrendt H et al (1992) Multiple Angiolipoma-analgesic therapy with doxepin. Dermatologist 43: 139-142
3. De Poortere DA et al (2012) Nasal tip angiolipoma: the "Pinocchio" nasal deformity. Ear nose throat J 91:E1-4.
4. Garib G et al (2015) Autosomal dominant familial angiolipomatosis. Cutis 95:E26-29.
5. Gaskin CM et al (2004) Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. AJR Am J Roentgenol 182: 733-739
6. Kitagawa Y et al (2014) Subcutaneous angiolipoma: magnetic resonance imaging features with histological correlation. J Nippon Med Sch 81:313-319.
7. Sheng Wet al (2013) Cellular angiolipoma: a clinicopathological and immunohistochemical study of 12 cases. At J Dermatopathol 35:220-225.