Angioedema acquiredT78.3

Differently defined group of diseases. Originally, the adjective "acquired" was used to refer to "acquired C1-esterase inhibitor deficiency" and thus was used in opposition to hereditary angioedema (see below complement system). However, "acquired" forms of angioedema in the broader sense also include:

• Histamine-mediated angioedema without C1-INH deficiency (often partial picture or equivalent of acute or chronic urticaria).
• Idiopathic angioedema without C1-INH deficiency
• Drug-induced angioedema without C1-INH deficiency (pharmacologically induced by drug inhibition of the renin-angiotensin system - ACE inhibitors/angiotensin II receptor blockers; they are bradykinin-mediated)
• Trauma-induced angioedema.

Type I (acquired angioedema, AAE I): partly with lymphoproliferative malignancies, e.g. malignant lymphoma.

Type II (AAE II): like AAE I, detectable antibodies against C1-INH.

Quantitative and/or functional_{C1 esterase inhibitor deficiency}. Pronounced C1q deficiency.

Drug-induced, e.g., by ACE inhibitors, ciclosporin A, or other drugs (e.g., hawthorn extracts [Crataegutt] and others).

Furthermore, the formation of antibodies against the active site of the_{C1 inhibitor} as well as the activation of the complement cascade by anti-idiotypic antibodies with excessive consumption (AAE type II) are described.

See below Angioedema hereditary.

1. Kirkup ME et al (2003) Experience with tranexamic acid for nonheriditary angio-oedema and urticaria. Br J Dermatol 149 (Suppl 64): 25-26
2. Nashan D et al (1995) Life-threatening angioedema due to acquired C1-inhibitor deficiency associated with paraproteinemia and livedo racemosa. Dermatologist 46: 339-342
3. Nettis E (2003) Clinical and aetiological aspects in urticaria and angio-oedema. Br J Dermatol 148: 501-506
4. Netzwerk aktuell (2010) Angioedema caused by hawthorn extract (Crataegutt Novo). Medication telegram 41: 54