Ammonium bituminosulfonate dark

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

Last updated on: 29.10.2020

Definition
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Sulphur oil obtained by dry distillation of high-sulphur bituminous slate (from Seefeld and Bächental/Tyrol, Meride/Ticino, Northern Italy and Southern France), sulphur oil sulphonated at high heat with concentrated sulphuric acid and neutralised with ammonia, evaporated to form a syrupy consistency ( slate oil, stone oil).

Pharmacodynamics (Effect)
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Antiphlogistic, antiseborrhoeic, anti-eczematous, antipruriginous, antibacterial, antimyctic and circulation-promoting. Inhibition of hyaluronidase, sebaceous gland secretion, leucocyte migration and the release of chemotactic factors from granulocytes. Reduction of dandruff formation by reducing cell proliferation (antimitotic effect). In high concentration mild skin irritation.

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Indication
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Inflammatory and/or itchy skin diseases, especially boils, carbuncles and abscess formation.

Dosage and method of use
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5-10%: For superficial, inflammatory diseases of the skin, apply 1 time a day.

20-50%: in case of furuncles, sweat and sebaceous gland abscesses, apply once/day under occlusion for 3-5 days.

50% and more: viscous application form known and used for decades as "black traction ointment", which is used to "mature" abscesses.

Standard concentration
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5-50% in hydrophilic ointments, hydrophilic creams (O/W emulsion ointments), carmellose gel, hydroxyethyl cellulose gel.

Notice! In formulations with lipophilic bases the possibility of adding water is limited and depends on the ammonium bituminosulfonate concentration as well as on type and quantity of emulsifiers and other ingredients. Ammonium bituminosulfonate is best processed with water-free fat bases!

Undesirable effects
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Skin redness; irritation; rarely eczema, contact dermatitis, allergic.

Incompatibility
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W/O emulsion ointments and O/W emulsion ointments with non-ionic emulsifiers (liquefaction and breaking of the system). From 30% with polyethylene glycol ointment bases strong consolidation to rubbery products. Furthermore, incompatibilities are possible with cellulose esters, alkaloid salts (potash or caustic soda lye cause the release of ammonia), ampicillin, lead salts, hydroxyquinoline, iodine, iodides, iodoform, cation-active substances, quaternary ammonium compounds, alkaline earth and heavy metal salts.