DefinitionThis section has been translated automatically.
Urostatic: Inhibition of xanthine oxidase (reduction of uric acid synthesis), resulting in increased excretion of water-soluble precursors (xanthine, hypoxanthine); feedback inhibition of purine synthesis.
IndicationThis section has been translated automatically.
Primary and secondary hyperuricemia, gout kidney, urate nephrolithiasis, enzyme defect with overproduction of uric acid.
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Dosage and method of useThis section has been translated automatically.
Initial dose 300 mg/day or less (administration after breakfast), dose adjustment at 2-weekly intervals according to uric acid level (target: 4-6 mg/dl), maximum daily dose 800 mg/day (2 ED); maintenance dose 200-400 mg/day; dose reduction in renal failure (scheme adapted to creatinine clearance).
Undesirable effectsThis section has been translated automatically.
Pruritus, lichenoid and multiforme exanthema, urticaria, GIT disorders, bone marrow depression. Hypersensitivity syndrome (a total of 100-150 cases have been published in the literature) with a generalized course (fever, lichenoid or multiform exanthema, headache and limb pain, hepatitis, kidney failure). Cave! Often lethal course (20-30%)! The hypersensitivity syndrome occurs more frequently with simultaneous administration of thiazides and furosemide (see below toxic epidermal necrolysis).
InteractionsThis section has been translated automatically.
Azathioprine and 6-mercaptopurine are eliminated at a slower rate, the effect of salicylates and anticoagulants are enhanced, rashes are more common with amoxicillin and ampicillin, captopril increases the risk of leukopenia.
ContraindicationThis section has been translated automatically.
Pregnancy and lactation.
PreparationsThis section has been translated automatically.
Zyloric®
Prof. Dr. med. Peter Altmeyer