DefinitionThis section has been translated automatically.
Synthetic third generation polyaromatic retinoid with anti-inflammatory activity. Keratolytic.
IndicationThis section has been translated automatically.
Approved for acne therapy, e.g. acne comedonica, acne papulopustulosa. Good effects with actinic keratoses and lentigines were achieved by daily application of a 0.3% gel ( off-label use).
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Dosage and method of useThis section has been translated automatically.
Apply thinly 1 time a day after thorough skin cleansing to the entire affected skin area. Treatment usually lasts up to 12 weeks.
Standard concentrationThis section has been translated automatically.
0.1% as gel or cream.
Undesirable effectsThis section has been translated automatically.
Erythema; skin burning.
PreparationsThis section has been translated automatically.
Differin Gel, Differin Cream; Epiduo Gel (combination with BPO)
Note(s)This section has been translated automatically.
Remember! No prolonged sunbathing or UV-radiation under therapy (phototoxicity). Caution also in high mountains and at the sea!
LiteratureThis section has been translated automatically.
- Gollnick H (2003) Current concepts of the pathogenesis of acne: implications for drug treatment. Drugs 63: 1579-1596
- Gollnick HP, Krautheim A (2003) Topical treatment in acne: current status and future aspects. Dermatology 206: 29-36
- Greenspan A et al (2003) Cumulative irritation comparison of adapalene gel and solution with 2 tazarotene gels and 3 tretinoin formulations. Cutis 2003 72: 76-81
- Ioannides D et al (2002) Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial. Br J Dermatol 147: 523-527
- Millikan LE (2003) The rationale for using a topical retinoid for inflammatory acne. At J Clin Dermatol 4: 75-80
Prof. Dr. med. Peter Altmeyer