Sh-oligopeptide-5 (inci)

SH-oligopeptide-5 ("sh" is the acronym for "synthetic and human") is a recombinant, synthetic, human oligopeptide. "Oligopeptide" generally refers to a linear peptide chain of up to 10 amino acids (usually alpha-amino acids) linked together by peptide bonds (amide bonds).

SH-oligopeptide-5 refers to the synthetic oligopeptide-5 produced by genetically manipulated E. coli strains using bioengineering technologies. The starter gene is an exact synthetic copy of the human gene coding for "ARS interacting multi-functional protein 1" (AIMP1). ARS-interacting multi-functional protein 1 is a cytokine involved in the regulation of angiogenesis, immune activation and proliferation of fibroblasts.

SH-oligopeptide-5 is used in cosmetic formulations. The peptide mixture acts as a skin protection agent (protects the skin from external influences).

1. Kim SY et al (2013) ARS interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of β-catenin via fibroblast growth factor receptor 2-mediated activation of Akt. Stem Cells Dev 22: 2630-2640. https://www.ncbi.nlm.nih.gov/pubmed/23672191