Nonoxinol 9

Nonoxinol 9 is a non-ionic surfactant from the group of nonylphenol ethoxylates. It is used as an active ingredient in locally applied contraceptives because of its spermicidal effect. Nonoxinol is a clear, colourless to light yellow, viscous liquid.

Spermicidal action: Nonoxinol-9 attacks the membrane of the sperm. If the membrane is destroyed, the sperm are immobilized. Nonoxinol-9 is contained in many creams, gels, contraceptive suppositories and foams.

Antiviral effect: Laboratory tests have shown that nonoxinol-9 also attacks the membrane of the HIV virus; on the other hand, a vaginal wall attacked by nonoxinol-9 is also much more permeable to all types of viruses, so that there is practically no protection against viruses.

Frequent use leads to local irritation of the vaginal mucosa. Nonoxinol-9 may increase the infectiousness for sexually transmitted diseases if used frequently. There is also statistical evidence of a link between nonoxinol-9 use and urinary tract infections. Allergic reactions also occur in rare cases.