Synonym(s)
1-(4-isopropylphenyl)-3-phenyl-1,3-propanedione; 4-isopropyl-dibenzoylmethane; CAS number: 63250-25-9
DefinitionThis section has been translated automatically.
Isopropyl dibenzoylmethane is a substance with the molecular formula: C18H18O2 which is used as UV absorber in cosmetic formulations. It is highly soluble in ethanol and fats. Isopropyl dibenzoylmethane has a UV absorption maximum between 310 and 360 nm.
Undesirable effectsThis section has been translated automatically.
Contact and photoallergic reactions to 4-isopropyl-dibenzoylmethanes are not uncommon (de Groot AC et al. 1987; Schauder S et al. 1988); see also eczema photoallergic. In a larger collective (n=57) of patients with photocontact sensitisation (see photoallergen), oxybenzone and isopropyl dibenzoylmethanes were identified as the most frequent triggers (Journe F et al. 1999).
Trade namesThis section has been translated automatically.
Eusolex 80201
LiteratureThis section has been translated automatically.
- Darvay A et al (2001) Photoallergic contact dermatitis is uncommon. Br J Dermatol 145:597-601.
- de Groot AC et al (1987) Contact allergy to 4-isopropyl-dibenzoylmethane and 3-(4'-methylbenzylidene) camphor in the sunscreen Eusolex 8021. contact dermatitis 16:249-254.
- Journe F et al (1999) Sunscreen sensitization: a 5-year study. Acta Derm Venereol 79: 211-213.
- Marguery MC et al(1996) Contact allergy to 3-(4' methylbenzylidene) camphor and contact and photocontact allergy to 4-isopropyl dibenzoylmethane. Photodermatol Photoimmunol Photomed 11(5-6):209-212
- Schauder S et al (1988) Photoallergic and allergic contact eczema caused by dibenzoylmethane compounds and other sunscreening agents. Dermatologist 39:435-440.
Prof. Dr. med. Peter Altmeyer