Hexamedine diisethionates (inci)

Hexamedine diisethionate is a chemical compound from the group of dibenzamidines. The substance is used in cosmetic formulations as preservative and antifoam agent. Medically, hexamidine diisethionate is used as a disinfectant for external application.

Indication: Hexamidine diisethionate solutions are indicated as additional treatment for skin infections and for infected or possibly infected mucous membranes.

Adverse effects: Allergic skin reactions up to rare anaphylactic reactions are possible (Revuz J et al. 1984; Mullins RJ 2006). Occasionally photoallergic reactions have been reported (Boulitrop-Morvan C et al. 1993).

The framework conditions for preservatives that may be used in cosmetics are defined in the EC Cosmetics Regulation (1223/2009) Annex V.

Preparation: Hexomedine Transdermal®

1. Boulitrop-Morvan C et al (1993) Photoallergy to hexamidine. Photodermatol Photoimmunol Photomed 9:154-155.

2. Revuz J et al (1984) Contact dermatitis from hexamidine. Ann Dermatol Venereol 111:805-810.

3. Mullins RJ (2006) Systemic allergy to topical hexamidine. Med J Aust 185:177.