DefinitionThis section has been translated automatically.
Tyrosinase-related protein (TYRP) is the obsolete name for two enzymes:
- TRP-1: 5,6-dihydroxyindole-2-carboxylic acid oxidase
- TRP-2: L-dopachrome tautomerase
General informationThis section has been translated automatically.
The TRYP-1 gene encodes the enzyme "5,6-dihydroxyindole-2-carboxylic acid oxidase" also DHICA oxidase, which catalyses 5,6-dihydroxyindole-2-carboxylic acid in melanin. Mutations in the TYRP1 gene are responsible for oculocutaneous albinism type 3. Animals immunized with this enzyme show the symptoms of Vogt-Koyanagi-Harada syndrome. One allele of TYPR1 in humans is characteristic for blonde-haired inhabitants of the Solomon Islands. Remarkably, this allele does not occur in Europeans. Apparently, melanocytes of Vitiligo under stress express a tyrosinase-related protein that is recognized by the immune system as foreign.
LiteratureThis section has been translated automatically.
- Shield M et al (2016) Vitiligo. dermatologist 67: 173-186
Prof. Dr. med. Peter Altmeyer