Rupatadine
DefinitionThis section has been translated automatically.
second-generation antihistamine, which has been approved in Germany since mid-2008 for the symptomatic treatment of allergic rhinitis and chronic urticaria in adults and adolescents (12 years and older).
Pharmacodynamics (Effect)This section has been translated automatically.
Rupatadine has a dual mechanism of action with its specific antihistaminergic and PAF-antagonistic effects. Comparative studies have shown an equally effective effect as the antihistamines cetirizine and ebastine with comparable therapeutic safety.
IndicationThis section has been translated automatically.
Rhinitis allergica, chronic urticaria, cold urticaria.
Dosage and method of useThis section has been translated automatically.
once/day 10 mg p.o.
Undesirable effectsThis section has been translated automatically.
The most frequently observed side effects are somnolence (9.5%), headache (6.9%), exhaustion (3.2%).
PreparationsThis section has been translated automatically.
Rupafin, Urtimed
Note(s)This section has been translated automatically.
Rupatadine should be used with caution in patients with a known long QT interval, uncorrected hypokalemia and pre-existing cardiac arrhythmias, and in clinically significant bradycardia or acute myocardial ischemia.
Note: Advantages over other antihistamines such as cetirizine are not well established.
LiteratureThis section has been translated automatically.
- Medication Telegram (2015) Pupatadine for allergic symptoms. Medication telegram 46: 47
- Fantin, S. et al (2008) A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy: 63: 924-31
- Martinez-Cocera et al (2005) Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study.1: J Investig Allergol Clin Immunol: 15: 22-29