DefinitionThis section has been translated automatically.
second-generation antihistamine, which has been approved in Germany since mid-2008 for the symptomatic treatment of allergic rhinitis and chronic urticaria in adults and adolescents (12 years and older).
Pharmacodynamics (Effect)This section has been translated automatically.
Rupatadine has a dual mechanism of action with its specific antihistaminergic and PAF-antagonistic effects. Comparative studies have shown an equally effective effect as the antihistamines cetirizine and ebastine with comparable therapeutic safety.
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IndicationThis section has been translated automatically.
Rhinitis allergica, chronic urticaria, cold urticaria.
Dosage and method of useThis section has been translated automatically.
once/day 10 mg p.o.
Undesirable effectsThis section has been translated automatically.
The most frequently observed side effects are somnolence (9.5%), headache (6.9%), exhaustion (3.2%).
PreparationsThis section has been translated automatically.
Rupafin, Urtimed
Note(s)This section has been translated automatically.
Rupatadine should be used with caution in patients with a known long QT interval, uncorrected hypokalemia and pre-existing cardiac arrhythmias, and in clinically significant bradycardia or acute myocardial ischemia.
Note: Advantages over other antihistamines such as cetirizine are not well established.
LiteratureThis section has been translated automatically.
- Medication Telegram (2015) Pupatadine for allergic symptoms. Medication telegram 46: 47
- Fantin, S. et al (2008) A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy: 63: 924-31
- Martinez-Cocera et al (2005) Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study.1: J Investig Allergol Clin Immunol: 15: 22-29
Prof. Dr. med. Peter Altmeyer