Prostaglandin h2

Prostaglandin H2, also called PGH2, is a chemical compound from the group of prostaglandins. It is a primary cyclooxygenase metabolite of arachidonic acid. PGH2 and prostaglandin G2 are organic endoperoxides. Prostaglandin H2 and prostaglandin G2 are converted enzymatically or non-enzymatically into prostaglandin E2, prostaglandin F2alpha and prostaglandin D2.

In various organelles and cells, especially the platelets, the PG endoperoxides are predominantly metabolized to thromboxane by the enzyme thomboxane synthase. In the vascular endothelia, the PG endoperoxides become a functional antagonist to the vasodilatory thrombboxane, which promotes thrombocyte aggregation.

Dietz R et al,(1988) Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2. Eur J Biochem 171:321-328.

Kulmacz RJ (1987) Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid. Prostaglandins 34:225-240.

Watanabe K et al (1985) Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung. J Biol Chem 260:7035-7041.