Prostaglandin g2

Prostaglandin G2, also called PGG2, are chemical compounds from the group of prostaglandins. Prostaglandin G2 is a primary cyclooxygenase metabolite of arachidonic acid. PGG2 and prostaglandin H2 are organic endoperoxides Prostaglandin G2 and prostaglandin H2 are converted enzymatically or non-enzymatically into prostaglandin E2, prostaglandin F2alpha and prostaglandin D2.

In various organelles and cells, especially the thrombocytes, the PG endoperoxides are predominantly metabolized to thromboxane by the enzyme thomboxane synthase. In the vascular endothelia, the PG endoperoxides become a functional antagonist to the vasodilatory thromboxane A2 (TXA2), which promotes platelet aggregation.

1. Dietz R et al,(1988) Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2. Eur J Biochem 171:321-328.
2. Kulmacz RJ (1987) Prostaglandin G2 levels during the reaction of prostaglandin H synthase with arachidonic acid. Prostaglandins 34:225-240.