Pneumonia, eosinophilic chronic J18.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

CEP; Chronic eosinophilic pneumonia; Eosinophilic chronic pneumonia, Chronic eosinophilic pneumonia

Definition
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Chronic eosinophilic pneumonia is a rare, aetiologically unexplained disease associated with blood eosinophilia (in 80% of cases) as well as systemic symptoms such as fever, chills, night sweats, cough, loss of appetite and weight loss.

Occurrence/Epidemiology
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w:m=2:1

Etiopathogenesis
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Often associated with allergic diathesis. Almost 50% of patients are preceded by bronchial asthma < 5 years.

Clinical features
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Chronic eosinophilic pneumonia (CEP) usually begins insidiously with systemic symptoms such as fever, chills, night sweats, cough, loss of appetite and weight loss. About 30% of patients suffer from bronchial asthma at the same time.

Imaging
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Thoracic radiographs often show peripheral (migrating) infiltrates.

Laboratory
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Blood eosinophilia (80%), significant IgE increase, p-ANCA positivity (50%).

Diagnosis
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Clinical picture, chest x-ray, BAL with >40% eosinophilia .

Therapy
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High-dose systemic glucocorticoids

Progression/forecast
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Very short-term and significant improvement of symptoms (within 48h) after the start of glucocorticoid therapy.

Literature
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  1. Sriratanaviriyakul N et al (2016) Chronic eosinophilic pneumonia presenting with ipsilateral pleural effusion: a case report. J Med Case Rep 10:227.
  2. Hirai J et al (2017) Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions anda
    review of the literature. J Infect Chemother 23:245-249.
  3. Kim NH et al (2015) Bronchial involvement in chronic eosinophilic pneumonia: a case report. J Thorac Dis 7: E97-E101
  4. Jaimes-Hernández J et al (2012) Chronic eosinophilic pneumonia: autoimmune phenomenon or immunoallergic disease? Case report and literature review. Reumatol Clin 8:145148.
  5. Shin YS et al. (2012)Successful treatment of chronic eosinophilic pneumonia with anti-IgE therapy. J Korean Med Sci 27:1261-1264.

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Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020