Osmotic gap

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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The calculation of the osmolality or the osmotic gap is used to determine intoxication with non-ionic low molecular weight substances such as methanol or ethanol.

General information
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Standard value: The reference range of osmolarity is between 280 - 300 mosmol/kg H2O. The reference range of the osmotic gap is < 6 mmol/l.

Pathologically elevated: Poisoning with non-ionic low molecular weight substances such as methanol or ethanol, hemorrhagic shock, ketoacidosis, lactic acidosis, pseudohyponatremia

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Last updated on: 29.10.2020