Nerd T88.7

Acronym for "NSAID exacerbated respiratory disease". The term "NERD" covers all patients with (non-immunological) NSAID hypersensitivity and respiratory symptoms. Clinical symptoms are blocked nasal breathing, rhinorrhoea, bronchial asthma. Many patients suffer from polyposis nasi, rhinosinusitis and/or bronchial asthma as the underlying disease.

1. Brandstätter H et al (2010) Immediate hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: allergy or pseudo-allergy? Rev Med Suisse 6:1345-1348
2. Hecksteden K et al (2003) Diagnosis of the analgesic intolerance syndrome by means of functional cell testing (Analgesic Intolerance Test: AIT). Allergology 26: 263-271
3. Kleine-Tebbe J et al.(2016) Food Allergy and Intolerance Distinction, Definitions and Delimitation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 59:705 722.
4. McNeil BD et al. (2015) Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature 519:237-241.
5. Pichler WJ et al (2016) Classification of Drug Hypersensitivity into Allergic, p-i, and Pseudo-Allergic Forms. Int Arch Allergy Immunol 171:166-179.
6. Seitz CS et al (2014) Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum trypt se? Allergy Asthma Clin Immunol 10:19.