Nares J31.0

Acronym for "non-allergic rhinitis with eosinophilia syndrome". The clinical picture is defined by a non-allergic inflammation of the nasal mucosa associated with eosinophilia. This clinical constellation usually occurs together with nasal polyps.

A precursor symptom of an acetylsalicylic acid-sensitive rhinitis is discussed. Recently, mainly autoimmune phenomena have been discussed.

30-40 years

Clinically, NARES is characterized by perennial rhinitis with nasal obstruction of breathing, recurrent sneezing attacks and possibly low-viscosity rhinorrhea. Associated are adenoids, recurrent infections, headache or head pressure related, intrinsic bronchial asthma.

Eosinophilia and elevated levels of tryptase, ECP, IL-1beta, IL-4, IL-6, IL-17, IFN-gamma, TNF-α and MCP-1 are detected in the nasal secretion of NARES.

Detection of eosinophilic granulocytes in the exfoliative cytology of the mucosa. Exclusion of an allergic genesis. Detection of possibly associated diseases like nasal polyps, intrinsic bronchial asthma.

The therapy of NARES has so far mainly consisted in the long-term administration of topical corticosteroids, possibly in combination with surgical measures.

Successes have been achieved with systemically applied interferons (e.g. Roferon).

1. Becker S et al (2016) Non-allergic rhinitis with eosinophilia syndrome is not associated with local production of specific IgE in nasal mucosa. Eur Arch Otorhinolaryngol 273:1469-1475
2. Cassano M et al (2011) Nares patients have more respiratory infections than allergic subjects. Int J Immunopathol Pharmacol 24:813-815.
3. Cavone L et al (2015) Increase in the Level of Proinflammatory Cytokine HMGB1 in Nasal Fluids of Patients With Rhinitis and its Sequestration by Glycyrrhizin Induces Eosinophil Cell Death. Clin Exp Otorhinolaryngol 8:123-128.
4. Gröger M et al (2012) Mediators and cytokines in persistent allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome. Int Arch Allergy Immunol 159:171-178.
5. Moneret-Vautrin DA et al (1990) Nonallergic rhinitis with eosinophilia syndrome a precursor of the triad: nasal polyposis, intrinsic asthma, and intolerance to aspirin. Ann Allergy 64:513-518
6. Perić A et al (2016) Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis. Int Forum Allergy Rhinol 6:392-397.