Synonym(s)
Ascites sialoglycoprotein 3 4 ,Tracheobronchial mucin 3 4 ,Testis mucin 3 4; ASGP 3 4; Cell Surface Associated 2 3; HSA276359 3; MUC-4 3 4; Mucin 4; Pancreatic adenocarcinoma mucin 3 4; Tracheobronchial 2 3
DefinitionThis section has been translated automatically.
A membrane-associated protein of the mucin family (MUC) formed by epithelial cells and encoded by a gene (MUC gene) located on chromosome 3q29. It is believed that the mucin4 protein plays a protective role in the vulnerable epithelia of the airways and the female genital tract. Changes in MUC4 expression have been shown to be associated with a number of inflammatory and neoplastic processes. Overexpression of the MUC4/sialomucin complex (SMC) can be detected in breast cancer, including sclerosed epithelial cell fibrosarcoma.
LiteratureThis section has been translated automatically.
- Doyle LA et al (2012) MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement. At J Surg Pathol 36:1444-14451.
Prof. Dr. med. Peter Altmeyer