Synonym(s)
GM-CSF
DefinitionThis section has been translated automatically.
Cytokine, granulocyte-macrophage colony stimulating factor.
Pharmacodynamics (Effect)This section has been translated automatically.
Proliferation and differentiation of progenitor cells of granulopoiesis, monocytes and macrophages, eosinophils, erythropoiesis and megakaryopoiesis Increase of the production rate of neutrophils by 50%, extension of the circulation half-life of neutrophils from 4 to 48 hours.
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IndicationThis section has been translated automatically.
Severe neutropenia in patients treated with myelotoxic chemotherapeutic agents.
Dosage and method of useThis section has been translated automatically.
5-10 μg/kg bw/day s.c.
Notice!
Therapy only under supervision of oncologically experienced doctors!Undesirable effectsThis section has been translated automatically.
Fever, nausea, vomiting, diarrhea, dyspnea, rigor, allergic reactions, fatigue, anorexia, bone pain, asthenia, non-specific thoracic pain, stomatitis, headache, sweating, pruritus, dizziness, peripheral edema, paraesthesia, myalgias.
InteractionsThis section has been translated automatically.
Decrease of the serum albumin level, possibly dose adjustment of drugs with high binding affinity to serum albumin.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, basic malignant myeloid disease (myelodysplastic syndrome, AML).
PreparationsThis section has been translated automatically.
Leucomax (available through the international pharmacy).
Prof. Dr. med. Peter Altmeyer