Levocetirizine

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Left-turning active R-enantiomer of cetirizine. Selective 2nd generation H1 antihistamine.

Pharmacodynamics (Effect)This section has been translated automatically.

Competitive H1 receptor antagonist. Levocetirizine binds to the H1-receptor, displaces the body's own histamine ligands and therefore causes a reduction in the intensity of allergic reactions. Due to its dissolution behavior, levocetirizine, in contrast to the H1 antihistamines of the 1st generation, no longer reaches the central nervous system or only in extremely small quantities.

IndicationThis section has been translated automatically.

Treatment of disease symptoms in general symptoms of allergic diseases, allergic rhinitis, urticaria.

Pregnancy/nursing periodThis section has been translated automatically.

Insufficient data on use during pregnancy and lactation. Should not be prescribed during pregnancy and lactation.

Dosage and method of useThis section has been translated automatically.

  • Tablets: Children > 6 years of age and adolescents from 12 years of age and adults: 5 mg p.o. once/day, in case of severe itching higher doses may be necessary.
  • Drops: adults/children > 12 years. 5 mg/day (20 trp.) p.o.

Notice! Dose adjustment for patients with reduced kidney function!

Undesirable effectsThis section has been translated automatically.

Occasionally headaches, migraines, fatigue, tiredness, dry mouth, stomach aches, rhinitis and pharyngitis.

InteractionsThis section has been translated automatically.

Alcohol consumption can be expected to have a stronger dampening or fatiguing effect.

ContraindicationThis section has been translated automatically.

Severe renal failure. Hypersensitivity to piperazine derivatives, malabsorption of glucose or galactose and lactose intolerance.

PreparationsThis section has been translated automatically.

Xusal, Xusal acute

Note(s)This section has been translated automatically.

Persons involved in road traffic must be informed that their ability to react may be reduced.

LiteratureThis section has been translated automatically.

  1. Bree F et al (2002) Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans. Fundam Clin Pharmacol 16: 471-478
  2. Lee DK et al (2003) Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. J Allergy Clin Immunol 111: 337-341
  3. Tedeschi A et al (2003) Chronic urticaria: a role for newer immunomodulatory drugs? Am J Clin Dermatol 4: 297-305
  4. Verster JC et al (2003) Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol 111: 623-627

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer