Latex hypersensitivity T78.4

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Definition
This section has been translated automatically.

Allergy or intolerance reaction to latex or additives (vulcanizers, accelerators, antioxidants) of the processing method In case of allergy mostly IgE-mediated immediate reaction, rarely type IV reactions.

Occurrence/Epidemiology
This section has been translated automatically.

After contact with surgical, examination, household gloves, plasters, respiratory masks, urine bags, intestinal tubes, etc. Overall increasing incidence. Risk group: Medical staff, atopic persons, children with spina bifida or urinary tract malformations.

You might also be interested in

Advertisment
Allergology
Structural formula of cinnamon alcohol.
Cinnamon alcohol

Unsaturated alcohol with a trans-substituted carbon-carbon double bond in the side chain. The isomeric cis-...

Continue reading

Etiopathogenesis
This section has been translated automatically.

The triggering of type I, type IV, pseudoallergic and irritant eczematous reactions by handling the ingredients contained in the respective product is described:
  • Type IV allergies (allergic contact eczema): accelerators (thiurams, thiocarbamates, benzothiazoles, thioureas), antioxidants, vulcanizers, dye additives, latex, epichlorohydrin (?).
  • Type I allergies (immunological contact urticaria): latex, corn starch powder (?).
  • Pseudoallergic reactions (non-immunological contact urticaria): corn starch powder (sorbic acid?).
  • Irritative eczematous skin reactions: occlusion effects (maceration), glove powder, disinfectant.

Clinical features
This section has been translated automatically.

S.u. eczema, contact eczema; contact urticaria; rhinitis allergica; neoprene allergy; anaphylaxis (allergy, type I reaction).

Diagnosis
This section has been translated automatically.

Prick test, intradermal test, scratch test, epicutaneous test, friction test, provocation test, RAST.

Therapy
This section has been translated automatically.

Avoid the allergen by wearing synthetic rubber gloves, e.g. made of PVC, polyethylene, nitrile rubber, styrene-ethylene-butylene-styrene or styrene-butadiene and if possible accelerator-free, non-powdered gloves .

Tables
This section has been translated automatically.

Reactions to latex gloves

Diseases

Trigger

Allergic reactions

Type IV allergies (allergic contact eczema)

Accelerators (thiurams, thiocarbamates, benzothiazoles, thioureas), antioxidants, vulcanizers, dye additives, latex, epichlorohydrin (?)

Type I allergies (immunological contact urticaria)

Latex, corn starch powder (?)

Pseudoallergic reactions

non-immunological contact urticaria

Corn starch powder (sorbic acid?), pressure and sweating urticaria

irritant eczematous skin reactions

occlusion effects (maceration), glove powder, disinfectant


Examination gloves

Manufacturer/distribution

Glove

Material

Accelerators according to manufacturer specifications

Powder

Thiurame

Dithiocarbamates

Benzothiazoles

Thioureas

Ansell Medical

Examtex Vinyl

PVC

-

-

-

-

+

Syndication

PVC

-

-

-

-

-

Nitratouch

NK

-

+

+

-

-

Ansell Edmont

Touch N Tuff

NK

-

+

+

-

-

Beiersdorf

Glovex vinyl

PVC

-

-

-

-

+

Glovex neoderm

SEBS

-

-

-

-

+

Dispex (sterile)

PET

-

-

-

-

+

Dispex (unsterile)

PET

-

-

-

-

+

Hartmann

Peha-soft-vinyl

PVC

-

-

-

-

-

Peha-fol

PET

-

-

-

-

-

Johnson & Johnson

Ethiparat (sterile)

PETMA

-

-

-

-

+

Ethiparat (non-sterile)

PETMA

-

-

-

-

+

OP gloves

Allegiance

Duraprene

NEOP

-

+

-

-

+

Duraprene Powderfree

NEOP

-

+

-

-

Johnson & Johnson

Allergard

SEBS

-

-

-

-

+

Hartmann

Peha-taft-syntex

SBSI

-

-

-

-

+

Literature
This section has been translated automatically.

  1. Ahmed DD et al (2003) Occupational allergies caused by latex. Immunol Allergy Clin North Am 23: 205-219
  2. Bonnekoh B, Merk HF (1992) Occupational dermatological relevance of a generalized latex anaphylaxis induced by inhalation in the medical field of activity. Z Hautkr 67: 532-534
  3. Chowdhury MM et al (2003) Natural rubber latex allergy in a health-care population in Wales. Br J Dermatol 148: 737-740
  4. Ebo DG et al (2004) Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy. Clin Exp Allergy 34: 137-144
  5. Ehl W et al (1988) Latex allergies as IgE-mediated immediate reactions. Allergology 5:182-187
  6. Fabro L et al (1989) Anaphylactic reaction to latex, an instant type allergen of increasing importance. dermatologist 40: 208-211
  7. Heese A et al (1989) Allergies and intolerance reactions to latex gloves in the medical field. Dt Ärztebl 46: 41-46
  8. Roest MA et al (2003) Insulin injection site reactions associated with type I latex allergy. N Engl J Med 348: 265-266
  9. Zeiss CR et al (2003) Latex hypersensitivity in Department of Veterans Affairs health care workers: glove use, symptoms, and sensitization. Ann Allergy Asthma Immunol 91: 539-545

Recommended articles

Advertisment
Allergology
Fish allergy: Prick test with detection of positive reactions to salmon and pike-perch proteins.
Fish allergy

Type I- Food allergy to various fish allergens. Clinically important is the distinction to a so-called "fis...

Continue reading
Allergology
Latex allergy. Prick test.
Latex allergy

Usually IgE-mediated type I reaction to latex-containing products (rarely type IV reactions). After contact...

Continue reading
Allergology
Acute urticaria: Acute exanthema with multiple, disseminated red wheals, which in places flow tog...
Urticaria (overview)

Frequent, acute or chronic, predominantly exanthematic, polyetiological clinical pictures with a relapsing ...

Continue reading
Advertisment
Dermatology
Allergy (overview)

Allergies manifest themselves in numerous organs, with skin and mucous membranes being particularly frequen...

Continue reading

Incoming links (1)

Tomato allergy;

Outgoing links (14)

Allergic rhinitis; Allergy (overview); Contact dermatitis (overview); Contact urticaria; Epicutaneous test; Friction test; Intolerance reaction; Intracutaneous test; Latex allergy; Neoprene allergy; ... Show all

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer Prof. Dr. med. Peter Altmeyer

Articlecontent