Late phase reaction

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Late reaction; Late reaction of IgE-induced allergic inflammation; Lipid reaction; Phase 2 reaction

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Late reaction of IgE-induced allergic inflammation. Inflammatory reaction occurring 3-8 hours after allergen contact.

General informationThis section has been translated automatically.

  • The allergen-mediated activation of mast cells leads to cytokine-mediated migration ( Interleukin 3, Interleukin 5, GM-CSF) of eosinophils, basophilic leukocytes and monocytes, which can trigger a new inflammatory reaction by releasing further inflammation mediators (ECP, EDN, MBP, histamine, leukotrienes). This leads to an indurated erythema formation on the skin.
  • In the bronchial tubes, however, bronchoconstriction and mucosal swelling due to cellular infiltration, edema formation and mucus secretion dominate.

LiteratureThis section has been translated automatically.

  1. Kay AB (1991) Asthma and Inflammation. J. Allergy Clin. Immunol. 87:893-910

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer