Late phase reaction

Synonym(s)

Late reaction; Late reaction of IgE-induced allergic inflammation; Lipid reaction; Phase 2 reaction

Late reaction of IgE-induced allergic inflammation. Inflammatory reaction occurring 3-8 hours after allergen contact.

The allergen-mediated activation of mast cells leads to cytokine-mediated migration ( Interleukin 3, Interleukin 5, GM-CSF) of eosinophils, basophilic leukocytes and monocytes, which can trigger a new inflammatory reaction by releasing further inflammation mediators (ECP, EDN, MBP, histamine, leukotrienes). This leads to an indurated erythema formation on the skin.
In the bronchial tubes, however, bronchoconstriction and mucosal swelling due to cellular infiltration, edema formation and mucus secretion dominate.