Inhalation allergies, occupational T78.4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Allergy caused by inhalation of allergens bound to the workplace.

Pathogen
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Mostly caused by proteins of mice and rats, more rarely flies, cockroaches, grasshoppers (depending on the professional activity). Sensitization is by inhalation.

Occurrence/Epidemiology
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Incidence in Great Britain: 21/1000 workers/year.

Clinical features
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Rhinoconjunctivitis and bronchial asthma; in case of percutaneous sensitization also protein contacticaria.

Laboratory
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Detection of specific IgE antibodies, total IgE

Diagnosis
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Remember! Testing of patient's own occupational substances (should also be tested on a healthy, occupationally non-exposed volunteer as negative control after consent!)

  • If not commercially available, the accused occupational substance can be crushed in glycerol and then used for prick testing. Again, perform negative control with glycerol simultaneously. Cave! Exclusion of contraindications, e.g. glycerol sensitization, before!
  • In addition to prick testing, lung function testing and, if necessary, provocation testing.

Differential diagnosis
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Therapy
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Allergen protection (e.g. through internal implementation), breathing masks.

Aftercare
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The occurrence of acute rhinoconjunctivitis with exclusive occupational exposure, positive skin tests with the accused protein, detection of specific IgE antibodies and absence of symptoms in the case of allergenicity substantiates the suspicion of the presence of an isolated, occupational inhalation allergy!

Note(s)
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In the case of positive proof of an occupational inhalation allergy, the presence of an occupational disease must be reported (BK 4301 of the Annex to the BKV).

Literature
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  1. Tas E et al (2007) Occupational inhalation allergy to the common housefly (Musca domestica). Dermatologist 58: 156-160

Incoming links (2)

Allergen; Allergen;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020