Inflammatory dendritic cell

Stone man R 1973

Inflammatory dendritic cells belong to the professional antigen-presenting cells (APC). They are derived from CD14+ monocytes and partly from dendric cells of the peripheral blood. Inflammatory dendritic cells develop reactively in case of acute or chronic tissue inflammation. They first migrate from the blood into the lesional tissue. There they assume the properties of dendritic cells (Klechevsky E 2015). In healthy, non-inflamed tissue they are completely absent. IDCs later migrate from the inflamed tissue into the draining lymphatic organs, where they present antigens to naive T cells.

IDCs express CD1a and CD1c, CD206 and other surface markers (Brüggen MC et al. 2016). Furthermore, IDCs have been shown to induce NO synthase and that NO is an important metabolic regulator of IDCs (Everts B et al. 2012). IDCs secrete interleukin-1beta, TNF-alpha, interleukin-6 and interleukin-23 in vitro and are thus able to stimulate the Th17 lymphocyte response.

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