Synonym(s)
ITAM
DefinitionThis section has been translated automatically.
Immunoreceptor tyrosine-based activation motifs", ITAMs for short, are highly conserved peptide segments in the cytosolic portion of CD3. ITAMs are important components of the receptor complex belonging to CD3/TCR.
ITAMs are associated with tyrosine kinases and play an important role in signal transduction via the T cell receptor by phosphorylation.
Furthermore, ITAMs are important for B cell development and the activation of B cell receptors and Fc receptors.
Prof. Dr. med. Peter Altmeyer