IL10 Gene

The IL10 gene (IL10 stands for interleukin-10) is a protein-coding gene located on chromosome 1q32.1.

The protein of the same name encoded by the IL10 gene is a cytokine(interleukin-10) produced mainly by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects on immune regulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II Ag, and costimulatory molecules on macrophages. It also promotes B cell survival and proliferation and antibody production. IL10 can block NF-kappa B activity and is involved in the regulation of JAK-STAT signaling. Mutations in the IL10 gene are associated with increased susceptibility to HIV-1 infection and rheumatoid arthritis.

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