Ige, specific

Synonym(s)

Allergen-specific IgE; specific IgE; Specific IgE; VICTORY

Definition
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Classical parameter in allergological step-by-step diagnostics (anamnesis, skin testing, laboratory examination, provocation). The specific IgE (sIgE) describes that fraction of total IgE antibodies in serum whose specificity to certain allergens can be determined by in vitro test procedures. The detection of sIgE indicates that a specific sensitization to an allergen exists. Skin tests and determination of the sIgE are generally considered equivalent.

Indication
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Suspected IgE-mediated immediate type reaction, proof of sensitization. Impossible to perform skin tests in case of reaction anomalies of the skin (e.g. urticaria factitia, atopic dermatitis, etc.).

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Implementation
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Immunoassay, competitive or immunometric method using an enzyme, fluorescent, luminescent or radiolabeled reactant in the antigen-antibody reaction

Note(s)
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Test material = serum (1-2ml). Recently, approaches have been made to determine the antibodies in nasal secretion, as it has been shown that for a wide range of allergens there is a direct correlation between IgE levels in the blood and those in nasal secretion (Gökkaya M et al. 2020).

Literature
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Gökkaya M et al (2020) Nasal specific IgE correlates to serum specific IgE: First steps towards nasal molecular allergy diagnostic. Allergy 75:1802-1805.
Renz H et al (2009) In vitro allergy diagnostics. Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) Allergo J 19: 110-128