HypersensitivityT78.4
Synonym(s)
Hypersensitivity
DefinitionThis section has been translated automatically.
Hypersensitivity reactions are defined according to a consensus statement of the World Allergy Organization (WAO) as objectively reproducible symptoms caused by exposure to a specific stimulus (mainly drugs = ADR) in a dose that is easily tolerated by normal subjects. Accordingly, this definition includes both allergic (mediated by specific immunological mechanisms) and non-allergic (pseudoallergy, idiosyncrasy, intolerance) reactions.
By way of example, the following clinical pictures can be classified as hypersensitivity reactions:
- Urticaria
- angioedema
- anaphylactoid reactions after application of non-steroidal anti-inflammatory drugs (acetylsalicylic acid, diclofenac, indometacin)
- maculo-papular drug reactions
- Fixed drug reaction
- Symmetrical drug related intertriginous and flexural exanthema (SDRIFE)
- AGEP
- Erythema (exsudativum) multiforme
- DRESS
- TEN