Hydroxymethylpentylcyclohexenecarboxaldehyde

Hydroxymethylpentylcyclohexenecarboxaldehyde or also hydroxyisohexyl 3-cylcohexene carboxaldehyde (INCI label) belongs to the substance groups "Flavourings and perfumes/fragrances". Frequently used perfume (trade name Lyral ® and Kovanol®).

The sensitization rate in an average epicutaneous test sample is in different ranges. cohorts is around 2%. Typical for the localisation, this synthetic fragrance most frequently causes contact allergic eczema in the axillary region.

The age group between 52-67 years is most frequently affected.

1. Carvalho R et al (2011) Hydroxyisohexyl 3-cyclohexene carboxaldehydes (Lyral®) as allergen: experience from a contact dermatitis unit. Cutan Ocul Toxicol 30: 249-250
2. Geier J (2017) Screening substances for fragrance allergy: Fragrance mixes and Peru balsam. Allergo J 26: 16-19
3. Hamann D et al (2013) Hydroxyisohexyl 3-cyclohexene carboxaldehydes (lyral) in patch test preparations under varied storage conditions. Dermatitis 24:246-248
4. Schnuch A et al (2012) Is hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitization declining in central Europe? Contact Dermatitis 67:47-49