Cysteinyl-leukotrienes

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

Cysteinylleukotrienes; Sulfidoleukotrienes

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).

Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

Group of leukotrienes (LTC4, LTD4, LTE4) formed by phagocytes, basophil and eosinophil granulocytes and mast cells. LTC4 is formed via LTA4 by enzymatic coupling with glutathione. LTD4 is formed by cleavage of the gamma-glutamyl from the glutathione part of the LTC4 molecule by gamma-glutamyl transpeptidase. Glycine is then removed by a dipeptidase leading to LTE4. The main excretion product of the cysteinyl-LT metabolism is LTE4 which is mainly excreted by the bile.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer