Cd137

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

4-1BB; CDw137; ILA; TNF receptor superfamily member 9; TNFRSF9; tumor necrosis factor receptor superfamily member 9

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DefinitionThis section has been translated automatically.

CD137 is a member of the "tumor necrosis factor (TNF) receptor family". CD137 is a costimulatory immune checkpoint molecule and is expressed by activated T cells, by CD8 cells to a higher degree than by CD4 cells.

General informationThis section has been translated automatically.

Furthermore, CD137 expressions are found on dendritic cells, B cells, follicular dendritic cells, NK cells, granulocytes and endothelial cells in inflammatory tissue.

Best characterized is the costimulatory activity of CD137 on activated T cells. Crosslinking of CD137 stimulates T-cell proliferation, IL-2 secretion. The interaction of CD137 with TRAF2 can be detected.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer