Synonym(s)
4-1BB; CDw137; ILA; TNF receptor superfamily member 9; TNFRSF9; tumor necrosis factor receptor superfamily member 9
DefinitionThis section has been translated automatically.
CD137 is a member of the "tumor necrosis factor (TNF) receptor family". CD137 is a costimulatory immune checkpoint molecule and is expressed by activated T cells, by CD8 cells to a higher degree than by CD4 cells.
General informationThis section has been translated automatically.
Furthermore, CD137 expressions are found on dendritic cells, B cells, follicular dendritic cells, NK cells, granulocytes and endothelial cells in inflammatory tissue.
Best characterized is the costimulatory activity of CD137 on activated T cells. Crosslinking of CD137 stimulates T-cell proliferation, IL-2 secretion. The interaction of CD137 with TRAF2 can be detected.
Prof. Dr. med. Peter Altmeyer