Benzalkonium chloride

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Substance belonging to the disinfectants(INCI name: benzalkonium chloride)

Indication
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Inflammation of the oral mucosa and throat and superficial skin infections.

Standard concentration
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1 mg in lozenges, 0.01-0.02% for mucous membrane rinses, 0.1% for wound rinses, 0.5% in hydrophilic ointments (absorption bases), hydrophilic creams, hydroxyethyl cellulose gel.

Undesirable effects
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Allergic reactions are described as type IV contact allergy. Anaphylactic reactions have also been described after local application.

Contraindication
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Children < 4 years.

Incompatibility
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Anion-active substances, non-ionic surfactants (e.g. polysorbates), oxidizing agents, bentonite, aerosil, fatty oils, citrates, alginates, iodides, nitrates, heavy metals (silver salts). Adsorption on natural rubber and plastics (polyvinyl chloride)!

Preparations
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Dequonal solution/spray, Dorithricin original throat tablets. For skin or instrument disinfection: Lysoform Killavon, Baccalin, Laudamonium, Lysoform, Cutasept, Freka-Derm colourless/coloured.

Literature
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  1. Dao H Jr edt al (2012) Sensitization prevalence for benzalkonium chloride and benzethonium chloride. Dermatitis 23:162-166
  2. Mezger E et al (2012) Anaphylactic reaction following administration of nose drops containing benzalkonium chloride. Head Face Med 8:29
  3. Okahara A et al (2013) Local toxicity of benzalkonium chloride in ophthalmic solutions following repeated applications. J Toxicol Sci 38:531-53

Incoming links (1)

Cationic emulsifiers;

Outgoing links (2)

Disinfectants; Inci identification;

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Last updated on: 29.10.2020